Structured literature review to inform future study design and economic modelling

Review of available literature to provide insight on gaps in the current evidence base and inform future data generation for economic models

The challenge

Our client wished to make informed decisions on the design and content of future observational studies and economic models to support reimbursement of their product.

This required an understanding of existing scientific, humanistic and economic evidence for sub-populations within a particular cardiovascular disease area to enable identification of any gaps in the literature.

The solution

We designed a comprehensive literature search to identify information on key topics and in relation to specific patient populations. Information on patient sub-groups was critically evaluated and provided as a detailed data report.

Data were analysed against strategic criteria and findings presented via an executive summary, written report and accompanied by a visual slide deck to facilitate internal communication.

Key results

We identified several gaps in the existing literature, including:

• Cardiovascular outcomes in several sub‑populations.
• Humanistic burden of the disease.
• Economic burden of the disease.

Recognition of the gaps in the data identified several key areas which would inform the design of future studies.

Value to the client

Following provision of the literature review and presentation in a comprehensive and accessible format, our client had a clear understanding of the current evidence base.

This insight allowed our client to make an informed judgement on the need and approach for additional evidence generation to support the reimbursement of their product.