Adelphi Values has an experienced global team of qualitative researchers, health economists, statisticians, creative scientists, clinicians and strategists with industry experience, who truly understand the need to develop evidence and communicate value throughout the product lifecycle.
Below is a selection of our projects, presented according to therapeutic or strategic/methodological area. It is not exhaustive, and we would be happy to provide further information on request.
Payer material development for vaccines in hepatitis A
e-v@luate platform on vaccines for hepatitis A
Burden of disease literature review on hepatitis A in the UK and Ireland
Hepatitis B
Systematic literature review of a treatment for chronic hepatitis B
Preparation of a NICE submission for a hepatitis B drug
SMC submission for a treatment for chronic hepatitis B
Database analysis to calculate the economic burden of hepatitis B in the UK
Hepatitis C
Therapeutic area strategy analysis and reporting in chronic hepatitis C virus
Biomarkers in the treatment of hepatitis C virus infected patients – personalised medicine
Maximizing the use of a treatment for hepatitis C-infected patients through personalised medicine – extending the tool to additional treatments
Treatment algorithm for hepatitis C treatment
One-pager value communication tool for Hepatitis C
Comprehensive literature research in chronic hepatitis C in Asian countries
Database development and analysis in hepatitis C
Concept elicitation and cognitive debriefing interviews with hepatitis C patients in multiple countries
Development of an EMA summary document for several instruments used in hepatitis C trials
Development of a PRO outcomes summary document and communications support in hepatitis C trials
Description, interpretation and analysis of pooled data related to the use of several questionnaires, scales and screening tests in three hepatitis C clinical trials
Conceptual model for patients with hepatitis C
Psychometric validation of a hepatitis C symptom checklist using phase III trial data
Treatment patterns, healthcare utilization and costs associated with the hepatitis C virus in Japan
Value dossier on a treatment for post liver transplant in paediatric patients
Development of an economic model for treatment in post-liver transplant in paediatric patients
Structured literature reviews on the burden of disease of nonalcoholic steatohepatitis (NASH)
Strategic review and recommendations for paediatric endpoints to assess pruritis in colostatic liver disease
Written critique of hepatology
Measures for use in patients with autosomal dominant polycystic kidney and liver disease: development and validation of a symptom measure and validation of a health survey
Development of the evidence base regarding treatment patterns, cost and burden of disease for patients with hereditary angioedema to support the use of a new treatment
Communications package in hereditary angioedema
Clinical endpoint review, recommendations and update of an FDA submission package in hereditary angioedema
Hereditary angioedema clinical trial endpoint review, recommendations and FDA PRO submission package
Pooled clinical trial validation analysis of a PRO primary endpoint in hereditary angioedema to include in FDA submission package
FDA meeting support for a hereditary angioedema submission
Evaluation of market research reports in hereditary angioedema to support PRO submission package
Analysis of Visual Analogue Scale (VAS) summary scores with Last Observation Carried Forward (LOCF) in hereditary angioedema
Psychometric validation analysis of VAS summary scores in hereditary angioedema
Patient interviews for the face and content validation of the Patient Global Impression in hereditary angioedema
Psychometric validation of the 6-item and 8-item composite severity scores in hereditary angioedema
Consulting on the linguistic validation of a hereditary angioedema questionnaire into French, German and Portuguese
Cognitive debriefing of a questionnaire in hereditary angioedema patients
Validation and modifications to a questionnaire in hereditary angioedema patients
Consultancy services for linguistic validation of a hereditary angioedema diary
Publication strategy to present the results of studies in hereditary angioedema
Patient interviews to support a PRO submission package in hereditary angioedema
PRO briefing document in hereditary angioedema
Strategic consulting and analysis in hereditary angioedema
Re-analysis of patient composite score in hereditary angioedema
Training materials for a PRO questionnaire in hereditary angioedema
Exploration of IQ as a relevant endpoint in Hunter’s syndrome
Endpoint review in Hunter’s syndrome
PRO dossier on the Disease Activity Score (DAS), Scales of Independent Behaviour-Revised (SIB-R), Behaviour Rating Inventory of Executive Function (BRIEF) and Vineland Adaptive Behaviour Scales (VABS) for Hunter’s syndrome
Strategic PRO and ObsRO analysis of a Hunter’s Syndrome clinical trial database
Regulatory support for questionnaires in Hunter’s syndrome
Strategic treatment pathways for treatment in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH)
Update to payer value decks in PAH and CTEPH
Framework for real world evidence generation in PAH and CTEPH
Strategic plan and real-world evidence toolkit in PAH and CTEPH
Consultancy on interpretation of phase III trial endpoints in PAH and CTEPH
Meta-analysis, systematic literature review, data extraction and report on an oral combination treatment of PAH
Systematic literature review, data extraction & report on sensitivity analyses and a meta-analysis of an oral combination treatment of PAH
Meta-analysis of an oral combination treatment of PAH
Meta-analysis of an oral treatment of PAH – exploratory analyses on the effect of administering additional PAH-specific therapy upon two additional endpoints
Literature review of pulmonary hypertension secondary to chronic obstructive pulmonary disease (COPD)
Utility assessment in PAH
Literature review of PAH secondary to chronic obstructive pulmonary disease (COPD)
Interpretation of clinical trial results in PAH
Cognitive debriefing interviews with patients with PAH
Network meta-analysis of combination therapies in PAH
Psychometric validation of the Living with Pulmonary Hypertension (LPH) questionnaire in PAH
PRO claims for PAH – endpoint review and regulatory support for the FDA and EMEA
PRO claims for PAH: endpoint review, regulatory support and qualitative patient interviews
Qualitative research to explore patient preference for modes of administration in PAH treatments
Budget impact model for an anti-hypertensive treatment
UK cost offset model of two treatments for hypertension
Preparation of an interactive report on a cost-offset model for a treatment for hypertension
Asian value dossier for hypertension
Heart study economic model in hypertension
Advisory board on hypertension
Cost model for a direct renin inhibitor medication for the treatment of hypertension
Validation of an adherence questionnaire for hypertension patients utilizing administrative data
Hypertension database analysis in Japan
Data management and reporting on a cardiovascular health outcomes project switching study in hypertension
Development of a compliance and persistence screener in hypertensive patients at risk for cardiovascular events
Validation of data analysis with an FDA response in orthostatic hypertension
Adaptation of a heart study economic model in hypertension to Korea
Validation of the hypertension / dyslipidaemia treatment satisfaction survey
Hypotension
Defence of the use of the Orthostatic Hypotension Questionnaire (OHQ) to demonstrate treatment benefit and labelling claim in neurogenic orthostatic hypotension
Validation of the OHQ in neurogenic orthostatic hypotension using clinical trial data
Key opinion leader interviews on neurogenic orthostatic hypotension
Evaluation of the current measurement strategy in neurogenic orthostatic hypotension
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