Cost-effectiveness models

Cost effectiveness models demonstrate the value of your product and benefits over the existing standard of care and are a key component of submissions to Health Technology Assessment (HTA) bodies, informing discussions with national, regional and local payers.

With a strong in-house team of health economists, we develop cost-effectiveness analyses from evidence generation (including statistical analysis, evidence synthesis and utility data generation) through to model interpretation for HTA submission, across a wide range of therapy areas from oncology through to rare diseases. Our team can support you with:

Evidence needs assessment and design of model framework

Provision of advice and recommendations regarding appropriate model structures for the indication of interest

Selecting early modelling approaches to gain insight into potential value drivers and support early dialogue and payer consultation

Building multi-indication value-based pricing models as an extension of the cost-effectiveness model framework

View a case study on a previous cost effectiveness project

Early cost-utility model to support product positioning and future HTA submissions

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Health Economics & Data Analysis

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Early cost-utility model to support product positioning and future HTA submissions

Supporting internal decision-making by providing an early indication of cost-effectiveness

The challenge

Our client’s new product for the treatment for benign prostatic hyperplasia (BPH) had recently entered phase III clinical trials and results were expected later that year. Economic evidence was needed for their HTA submission in order to show the benefit of their new product compared to both surgical and non-surgical treatments. Our client hoped to incorporate the results from the phase III clinical trial into a cost-utility model as soon as the data became available. Therefore, this model was intended to provide a framework and early indication of the results for future HTA submission and to inform decisions regarding product positioning within the treatment pathway.

The solution

We developed an early cost-utility model which could support the internal decision-making and included:

> A targeted literature search to inform the structure and inputs of the model > A review of the client’s phase II and phase III trial structures and expected results
> Development of decision trees to reflect each treatment pathway (surgical and non-surgical), providing options for positioning within the overall treatment pathway for BPH
> Building a cost-utility model with all relevant costs (direct and indirect) and utility values.

Key results

The preliminary results of the model showed the economic benefit associated with the new product in different treatment pathways. After running a number of deterministic and probabilistic sensitivity analyses, we were able to assess uncertainty in the results and identify the parameters which were likely to impact the overall cost-effectiveness, pending phase III trials results.

Value to the client

The cost-utility model gave an early indication of the benefits associated with the product and provided insight into how the different product parameters were likely to impact on the final cost-effectiveness results from a HTA model, dependent on final product positioning.